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Pharmalogical effect
Upsarin - medicine group of non-steroidal anti-inflammatory drugs. The preparation contains an active ingredient - acetylsalicylic acid. The drug has a pronounced anti-inflammatory, antipyretic and antiplatelet effect. The mechanism of action of aspirin is associated with its ability to inhibit the activity of both isoforms of cyclooxygenase, thereby slowing down the metabolism of arachidonic acid and decreased synthesis of prostaglandins, prostacyclins and thromboxane A2. Analgesic effect of the drug at the expense of reducing prostaglandins in the center of thermoregulation, thereby reducing its excitability. Conducting and drug reduces pain impulse generation and also reduces the intensity of the inflammatory process.
Upsarin Upsa with vitamin C - a complex preparation containing acetylsalicylic acid in addition to ascorbic acid. Vitamin C (ascorbic acid) is involved in redox reactions, regulates carbohydrate metabolism, synthesis of different substances, and blood clotting. In addition, vitamin C increases the regenerative capacity of tissue, and has a strong antioxidant effect.
After dissolution of the effervescent tablet is formed a buffer mixture which reduces the toxic effect of acetylsalicylic acid on the mucous membranes of stomach and duodenum, and also enhances the absorption of the active ingredient.
After oral administration of acetylsalicylic acid is well absorbed in the gastro-intestinal tract. Peak plasma concentration of acetylsalicylic acid observed after 15-40 minutes after oral administration, the bioavailability of dose-dependent and ranges from 60% to 90%. Acetylsalicylic acid is hydrolyzed in the body to form a pharmacologically active salicylic acid, besides the metabolism of acetylsalicylic acid, a number of pharmacologically active metabolites. The active ingredient of the drug and its metabolites cross the blood-placenta and blood-brain barrier and is excreted in breast milk. The half-life of acetylsalicylic acid is 15-20 minutes, salicylic acid - 2-4 hours, ascorbic acid, - from 12.8 to 29.5 days.
Acetylsalicylic acid mainly derived kidneys in unchanged form or in the form of metabolites.
Indications for use
The drug is used for the relief of pain of various etiologies, including its prescribed for toothache and headache, migraine, neuralgia, myalgia and joint pain, as well as algodismenoree.
The drug can be assigned as antipyretic agent with acute respiratory diseases, and inflammatory processes of various locations.
UPSARIN Upsa also prescribed for rheumatic disease, including acute manifestations of rheumatic fever and the ineffectiveness of other drugs, the drug can be assigned to children over the age of 7 years.
How to use
Effervescent tablets Upsarin Upsa:
The preparation is intended for preparing a solution for oral administration. Immediately before taking the tablet to be dissolved in 200ml drinking water or juice. The drug is taken with or without food. Care must be an interval of at least 4 hours between doses of the drug. The duration of treatment and the dose determined by the attending physician for each patient individually.
Adults and adolescents over the age of 15 years with a pain syndrome and elevated body temperature, usually on 1 tablet 1-6 times a day. If necessary, the dose was increased to two tablets of the same time.
The maximum daily dose Upsarin Upsa for adults and adolescents over the age of 15 years is 6 effervescent tablets (3000mg acetylsalicylic acid).
The maximum daily dose Upsarin Upsa for elderly patients is 4 effervescent tablets (2000mg acetylsalicylic acid). Elderly patients are contraindicated use of the drug at a dose of more than 500mg.
Do not take the drug for more than 3 consecutive days, if the treating physician does not otherwise directed.
Adults and adolescents over the age of 15 years with acute rheumatic pain usually on 1-2 effervescent tablets 3-4 times a day.
Elderly patients with acute rheumatic pain usually on one effervescent tablet 3-5 times a day.
Children under the age of 7 years with a body weight over 20 kg of acute rheumatic pain if other drugs are usually prescribed aspirin at a daily dose of 50mg/kg body weight. The daily dose should be divided into 4-6 doses.
Using the drug in patients noted the development of these side effects:
On the part of the gastrointestinal tract and liver: nausea, vomiting, stomachalgia, a violation of stool, anorexia, elevation of liver enzymes. In rare cases, noted the development of gastro-intestinal bleeding, symptoms of which are vomit color of coffee grounds and tarry stools.
Cardio-vascular system and blood: increased bleeding, decreased blood clotting, thrombocytopenia, anemia, increased bilirubin, leukopenia.
The central nervous system: dizziness, headache, ringing in the ears.
Allergic reactions: skin rash, pruritus, urticaria, bronchospasm, angioedema, non-cardiogenic pulmonary edema, anaphylactic shock. In patients with hypersensitivity may develop symptoms of "aspirin triad."
Other: renal failure. Mainly when using the drug in children under the age of 15 years may develop Reye's syndrome. If the daily dose Upsarin Upsa with vitamin C effervescent tablets is greater than 5, the formation of oxalate and urate.
In the case of side effects, stop medication and consult your doctor. In the case of gastrointestinal bleeding should immediately seek medical help.
Contraindications:
Hypersensitivity to the drug and other medicines of non-narcotic analgesics, including the use of the drug is contraindicated in patients with "aspirin" asthma.
UPSARIN Upsa not prescribed to patients suffering from phenylketonuria.
The drug is not prescribed to patients suffering from a deficiency of vitamin K, and glucose-6-phosphate dehydrogenase, as well as severely impaired liver and / or kidney disease and hemorrhagic diathesis.
The drug is contraindicated in patients with gastric ulcer and duodenal ulcer in acute, gastrointestinal bleeding, and severe diseases of the cardiovascular system, in particular portal hypertension, severe heart failure and dissecting aneurysm of the aorta.
The drug is not used for the treatment of women during pregnancy and lactation, as well as for the treatment of children under the age of 15 years. The exception is the short-term use of the drug Upsarin Upsa in children older than 7 years old weighing more than 20 kg of acute rheumatic pains.
The drug should be used with caution in patients with hyperuricemia, urate nephrolithiasis, gout and decompensated heart failure.
Caution must be exercised in the appointment of the drug to patients with a history of erosive and ulcerative lesions of the mucous membrane of the stomach and duodenum.
Patients who adhere to a salt-free diet, it should be borne in mind that each tablet effervescent UPSARIN Upsa contains 388.5 mg of sodium each effervescent tablet UPSARIN Upsa with Vitamin C - 485mg of sodium.
The drug should be discontinued 7 days prior to planned surgery.
Pregnancy:
Do not use this drug during pregnancy. Acetylsalicylic acid is teratogenic, when using the drug in the first trimester of pregnancy, the fetus may develop cleft palate. Using the drug in the third trimester of pregnancy may develop violations of labor and premature closure of the ductus arteriosus in the fetus.
If necessary, use during lactation should consult with your doctor and decide on the termination of breastfeeding.
Interactions with other drugs:
The combined use of the drug increases the toxic effects of methotrexate. Contraindicated combined use of these drugs, if the weekly dose above 15 mg methotrexate.
While the use of the drug increases the effectiveness of narcotic and non-narcotic analgesics, heparin anticoagulants, thrombolytics, sulfonamides, triiodothyronine, and hypoglycemic agents for oral administration.
Acetylsalicylic acid in the combined use reduces the toxic effects of uricosuric drugs and drugs with antihypertensive and diuretic effect.
The concomitant use of drugs with corticosteroids and ethanol increases the negative effect of acetylsalicylic acid on the mucous membrane of the stomach and duodenum, as well as increased risk of gastrointestinal bleeding.
The combined use of the drug enhances the plasma concentrations of barbiturates, digoxin and lithium preparations.
With the simultaneous use of the drug with antacid drugs containing magnesium and aluminum reduce the absorption of acetylsalicylic acid.
The drug may reduce the effectiveness of intrauterine contraceptive devices.
Synonyms:
Aspirin.
Ingredients:
1 effervescent tablet UPSARIN Upsa contains:
Acetylsalicylic acid - 500 mg;
Excipients, including aspartame.
1 effervescent tablet UPSARIN Upsa with Vitamin C contains:
Acetylsalicylic acid - 330mg;
Ascorbic acid - 200 mg;
Excipients.
