Klimadynon tablets 20mg #60

Klimadynon tablets 20mg #60

With over 50 million daily doses taken worldwide, Klimadynon alleviates menopause-related hot flashes, sweating, sleep disruption, anxiety and depressive emotional states. In a clinical trial comparing this black cohosh to hormone replacement therapy, Klimadynon was the first botanical extract to demonstrate in a double-blind placebo-controlled study that it acts as an organspecific phyto-selective estrogen receptor modulator (SERM). In this study, Klimadynon’s special extract of black cohosh (BNO-1055) also demonstrated that it had a positive effect on bone resorption markers by stimulating osteoplastin production. Bionorica’s outstanding research on black cohosh was recently recognized in a letter from the NIH’s Office of Dietary Supplements.
60 tablets 20 mg

Pharmacological action:
Klimadinon - plant origin (special extract BNO 1055 - CR) with a complex mechanism of action estrogenpodobnym. Active ingredients include black cohosh extract special organoselektivnye and highly specific phytoestrogens with severe dopaminergic, and organoselektivnym estrogen action on the female body. Used in the treatment of pre- menopausal disorders and substitution treatment with estrogen deficiency. Can also be used after removal of both ovaries of reproductive age. Active ingredients of black cohosh extract have an affinity to the estrogen receptors in the hypothalamus. Upon stimulation of these receptors decreases allocation luteinizing hormone-releasing hormone with a further decrease in the secretion of luteinizing hormone in the anterior pituitary. With a decrease in gonadotropin secretion observed relief and psycho-emotional disorders vegetovascular that are possible in the pre-and menopausal stages of life due to a sharp decrease in estrogen production, accompanied by a simultaneous increase in the secretion of luteinizing hormone and follicle-stimulating hormone. Special extract of black cohosh and positive effect on the metabolism of the bone, which is confirmed by the influence of biochemical markers of reparative processes in the bone tissue (bone- specific alkaline phosphatase and insulin-like growth factor). Clinical trials found that the effect of the special black cohosh extract from Bionorica AG (BNO 1055) is comparable with the effect of conjugation of estrogens on a scale of menopausal disorders MRS. Klimadinon (including Klimadinon DNA) stimulates the proliferation of epithelial cells of the surface of the vagina, does not cause a decrease in FSH below normal values ​​, which ensures its own production of estrogen and preservation of the natural functions of the ovaries.

Special black cohosh extract, unlike estrogen drugs, does not initiate endometrial proliferation and estrogen- stimulated proliferation of breast carcinoma.

Indications for use:
And psycho-emotional disorders vegetososudistye in pre- menopausal and periods that are accompanied by excessive sweating, hot flashes, sleep disturbances, depression, irritability.

Method of application:
Tablets Klimadinon Uno and Klimadinon swallowed with water. Do not chew. Drops for internal use Klimadinon drink undiluted or take on a piece of sugar. Klimadinon Uno appoint 1 tablet a day in the evening. Klimadinon tablets - 1 tablet 2 times / day. Drops Klimadinon appoint 30 drops 2 times / day.
Typically, the therapeutic effect of the drug develops within 14 days after the start of administration. The course of treatment is determined individually. Without consulting a specialist can take Klimadinon not more than 3 months.

Side effects:
• Abdominal pain transient nature (rare);
• a sense of tension in the breasts (very rare);
• menstrualnopodobnye selection (very rare);
• weight gain (very rare).

Contraindications:
• Allergic reactions to components Klimadinon;
• estrogen-dependent disease (since the clinical data on the use of the drug in these patients are not available).

Interaction with other drugs:
At the moment of interaction with various drugs have been identified.

Overdose:
Exceedances Klimadinon dosages are not known.

Form:
Klimadinon - coated tablets, 60 pieces per pack.
Klimadinon DNA - coated tablets, 30 pieces per pack.
Klimadinon - drops for internal use 50 mL vial.

Storage conditions:
In normal conditions. In Klimadinon drops over time may appear pellet or flake (from vegetable raw materials) that does not alter the activity of the components. Do not use in excess of the expiration date indicated on the packaging.

Ingredients:
tablets Klimadinon:
Active ingredient (1 tablet): rhizome extract of black cohosh (Cimicifuga Racemosa) dry - 20 mg.
Inactive ingredients: lactose monohydrate, talc, potato starch, iron oxide yellow, magnesium stearate, calcium hydrogen phosphate dihydrate, titanium dioxide (E171), macrogol 6000, iron oxide red (E 172), Eudragit RL 30 D.
drops Klimadinon:
The active ingredient (100 g): rhizome extract of black cohosh (Cimicifuga Racemosa) liquid - '12
Inactive ingredients: peppermint oil, ethyl alcohol, sodium dihydrate, sucrose, purified water.
Tablets Klimadinon OOE:
Active ingredient (1 tablet): rhizome extract of black cohosh (Cimicifuga Racemosa, (4,5-8,5:1) dry - 32.5 mg.
Inactive ingredients: lactose monohydrate, talc, potato starch, iron oxide yellow, magnesium stearate, calcium hydrogen phosphate dihydrate, titanium dioxide (E171), macrogol 6000, iron oxide red (E 172), Eudragit RL 30 D.

Extras:
Drops for receiving internal contain ethyl alcohol (35-40 vol. %). The tablets contain lactose. Not assigned to pregnant and lactating patients.

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