Mode of action:
Broad-spectrum antibiotic. Has bacteriolytic (destroys bacteria) action. It is active against a broad spectrum of aerobic (developing only in the presence of oxygen) or anaerobic (can exist in the absence of oxygen) and gram-positive aerobic gramotriiatelnyh microorganisms, including strains that produce beta-lactamase (enzyme that destroys penicillin). Part of the preparation clavulanic acid provides resistance to the effects of amoxicillin beta-lactamase, expanding the range of its validity.
Indications for use:
Bacterial infections caused by sensitive microorganisms: upper respiratory tract infection -ostrye and chronic bronchitis (inflammation of the bronchi), equity bronchopneumonia (combined inflammation of the bronchi and lungs), empyema (accumulation of pus), abscesses (ulcers) of the lungs; bacterial infections of the skin and soft tissues; urinary tract infections - cystitis (inflammation of the bladder), urethritis (inflammation of the urethra), pyelonephritis (inflammation of the tissues of the kidney and renal pelvis); septicemia (blood poisoning microbes from the source of purulent inflammation) abortion, pelvic infection, syphilis, gonorrhea; osteomyelitis (inflammation of the bone marrow and adjacent bone); septicemia (blood poisoning form of micro-organisms); peritonitis (inflammation of the peritoneum); postoperative infection.
How to use:
Before you assign patient drug to determine sensitivity to the hair that caused the disease in this patient. Dose is determined individually, depending on the severity, localization of infection and susceptibility.
Children younger than 1 year old drug is given in the form of droplets. The dose for children up to 3 months. - 0.75 ml, for children from 3 months. To - 1.25 ml. In severe cases, intravenous single dose for children under the age of 3 months. to 12 years is 30 mg / kg body weight; the drug is administered every 6-8 hours. Children under 3 months administered a single dose of 30 mg / kg of body weight: preterm and children in the perinatal period (on the 7th day of life births) - every 12 hours, then every 8 hours. Treatment drug should not continue for more than 14 days without review the clinical situation.
Children under the age of 12 years prescribed medication in the form of a syrup or suspension. Single dose depends on age and is: for children aged 7-12 years - 10 ml (0.156 g / 5 ml) or 5 ml (0.312 g / 5 ml); for children aged 2-7 years - 5 ml (0.156 g / 5 ml); children between the ages of 9 months. aged 2 - 2.5 ml of the syrup (0.156 g / 5 ml) 3 times a day. In severe infections, these doses may be doubled.
Adults and children older than 12 years with mild to moderate infections prescribed 1 tablet (0.375 g) 3 times a day. In severe infection single dose of 1 tablet. 0.625 g or 2 tab. 0.375 g of 3 times a day. It is also possible intravenous administration of a single dose of 1.2 g every 6-8 hours. When necessary, the drug can be administered every 6 hours. Maximum single dose is 1.2 g, the maximum daily dose when administered intravenously - 7.2 g
Patients with impaired renal excretory function, moderate or severe requires correction dosing regimen of the drug. Creatinine clearance (the rate of blood clearance from the end product of nitrogen metabolism -: creatinine) greater than 30 ml / min do not require changes in the dosing regimen; at 10-30 ml / min - the initial dose is 1.2 g intravenously, followed by 0.6 g every 12 h. When creatinine clearance less than 10 mL / min starting dose is 1.2 g, then 0.6 g of every 24 hours. Augmentin displayed by dialysis (blood purification process). In the case of the drug in patients undergoing dialysis, appoint additional intravenous administration of the drug at a dose of 0.6 g during and 0.6 g at the end of dialysis.
Augmentin should not be mixed in the same syringe or dropper with aminoglycoside antibiotics, since the inactivation occurs (loss of activity) of the latter. The drug should not be mixed with blood products and protein soderzhashih (containing protein) fluids.
Side effects:
Rarely - dyspepsia (indigestion). Severity of dyspeptic side effects may be reduced while taking the drug with food. Separate cases of hepatic dysfunction, the development of hepatitis, cholestatic jaundice (jaundice associated with the stagnation of bile in zhelchevyvodyashih ways). There are few reports on the development of pseudomembranous colitis (intestinal colic, characterized by bouts of abdominal pain and release of a large amount of mucus in the feces). Rarely -krapivnitsa, angioedema (allergic edema); very rare - anaphylactic (allergic) shock poliformnaya erythema (infectious-allergic disease characterized by redness of the skin and symmetrical rise in temperature), cider, Stevens-Johnson (a disease characterized by redness and bleeding in the mucous membranes of the mouth, urethra and conjunctiva / outer membrane of the eye /), exfoliative dermatitis (redness of the skin of the whole body with its expressed ecdysis). Rarely -kandidoz (a fungal disease) and other types of superinfection (severe, rapidly evolving forms of infectious disease caused by resistant microorganisms, formerly in the body, but does not show itself). In some cases, the opportunity to develop phlebitis (inflammation of a vein) at the injection site.
Contraindications:
Hypersensitivity to the drug.
Intravenously should be used with caution in patients with severe hepatic impairment. When the urticaria or erythematous rash treatment should be discontinued.
Use the drug during pregnancy (especially in the first trimester) and breastfeeding is not recommended.
The drug should be used with caution in patients with an indication of an allergic reaction in history (history).
Product:
Tablets 0.375 g; Tablets of 0.625 g syrup bottles.
Dry matter for suspension and suspension forte. Dry substance for the preparation of drops.
Powder for injection 0.6 g vials. Powder for injection 1.2 g
Ingredients:
In tablets, 0.375 g contained: 0.25 g amoksiiillina and 0.125 g of clavulanic acid; Tablets 0.625 g contains 0.5 g of amoxicillin and 0.125 g of clavulanic acid. 5 ml syrup contains: 0,156 contain g / 0,125 g of amoxicillin and clavulanic acid 0.03125 g / or 0.312 g / g 0.25 0.0625 g of amoxicillin and clavulanic acid /.
1 spoonful of dry matter for the preparation of suspension contains 0.125 g of amoxicillin and clavulanic acid 0.031 g; 1 spoonful of dry matter for suspension forte contains: 1 scoop contains 0.25 g of amoxicillin and clavulanic acid 0.062 g.
1 ml sample of dry matter for the preparation of drops contain: 0.05 g of amoxicillin and clavulanic acid 0.0125 g. In dosage forms for oral administration (by mouth) the application is in the form of amoxycillin trihydrate and clavulanic acid - as the potassium salt.
In the powder for injection 0.6 g contained 0.5 g and 0.1 g of amoxicillin clavulanic acid. Powder for injection contains 1.2 g 1.0 g 0.2 g of amoxicillin and clavulanic acid. As the dosage forms for intravenous administration, amoxicillin is in the form of sodium salt, and clavulanic acid - as the potassium salt. Each vial contains 1.2 g to about 1.0 mmol and 3.1 mmol potassium carbonate.
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