Mode of action:
Pharmacodynamics. Antral - hepatic drug from the group, and has a strong preventive and therapeutic effects in acute and chronic hepatitis of various etiologies, cirrhosis of the liver, reduces the symptoms and manifestations astenovegetativnogo dyspeptic syndrome, promotes the normalization of sleep and appetite. A course of use of the drug reduces the level of bilirubin, blood enzyme activities of alanine aminotransferase and aspartate aminotransferase normalization of gamma globulins, prothrombin index.
Antral has a prolonged anti-inflammatory, analgesic, antipyretic action, has immune-effect. Use of the drug reduces the damaging effects of various toxic substances on the cells of the liver, activates the regenerative processes in the hepatocytes of the liver and normalizes its structure. Antral stimulates antioxidant systems, stabilizes the structure of liver cells and liver as a whole. Being relatively safe pharmaceutical agent Antral no adverse effect on the operation and function of various organs and systems. The drug has a cumulative quality, does not have immunotoxic, local irritating, ulcerative, teratogenic and embryotoxic action.
Pharmacokinetics. Upon receiving the maximum level of the drug in the blood observed after 3-4 hours. Excretion occurs in the urine and feces. The half-life of 4-5 hours.
Indications for use:
Antral prescribed to adults and children with acute and chronic hepatitis of various etiologies, including viral, alcoholic, toxic, allergic and drug-induced, liver cirrhosis and fatty degeneration, inflammatory diseases of the gastro-intestinal tract, the condition after cholecystectomy.
In addition to treatments Antral may be given prophylactically to prevent the development of liver disease during chemotherapy and radiation therapy, the need for long-term use of drugs, food and other poisonings. The drug is used to prevent the development of chronic hepatitis and cirrhosis of the liver after acute viral hepatitis.
How to use:
Antral administered orally after meals three times a day. Children older than 10 years and adults appoint 0.2 g per dose, for children from 4 to 10 years - 0.1 g per reception. Adult liver cirrhosis within the first week of treatment, the drug administered to 0.4 g per dose, and then for 2-3 weeks 0.2 g reception. In cirrhosis of the liver in children 4-10 years old single dose of 0.1 g
The course of treatment is 3-4 weeks. A second course of treatment prescribed in 3-4 weeks. The duration of treatment is assigned a doctor, depending on the disease.
Antral take 20-30 minutes after eating a small amount of water.
Antral well tolerated. In some cases, chronic administration may develop dyspepsia, which rapidly disappear after cessation of treatment.
Acceptance of the drug is contraindicated in individual hypersensitivity to any components of the drug, kidney failure with reduced excretory functions, for younger children up to 4 years.
Antral is not recommended during pregnancy and lactation due to insufficient follow-up of its use.
Interactions with other drugs:
The drug can be used in treatment with antibacterial, choleretic, vitamin preparations, conducting detoxification. Antral not reduce the activity of steroid hormones and cytostatics. With a drug may reduce in half-dose corticosteroids without reducing the effectiveness of therapy.
With a possible drug overdose gastric lavage is necessary, followed by symptomatic treatment.
Antral discharged into capsules containing 0.1 to 0.2 g, packed in blisters 10 and 30 capsules.
The drug should be stored in a dry, dark place at a temperature of 25 degrees Celsius.
Antral capsule preparation contains 0.1 or 0.2 g of tris [N (2,3-dimethylphenyl) anthranilate] aluminum
Additional material: potato starch, magnesium carbonate, calcium stearate, Aerosil, methylcellulose, titanium dioxide, lactose monohydrate.
Taking the drug has no effect on the ability to drive vehicles and work with complex mechanisms.