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Actovegin (Actovegin)
Pharmacological Effects:
Actovegin activates cell metabolism (metabolism) by increasing the transport and accumulation of glucose and oxygen, increasing their intracellular disposal. These processes lead to the acceleration of the metabolism of ATP (adenosine triphosphate), and increase energy cells. Under conditions that restrict the normal functions of energy metabolism (hypoxia / insufficient oxygen supply or violation of its assimilation / lack of substrate) and with increased consumption of energy (healing, regeneration / tissue repair /), Actovegin stimulate energetic processes of the functional metabolism (the process of metabolism in body) and anabolism (the process of assimilation of substances by the body). Secondary effect is to increase blood flow.
Indications:
Cerebrovascular insufficiency, ischemic stroke (insufficient supply of brain tissue oxygen due to acute ischemic attacks), head injuries, disorders of peripheral circulation (arterial, venous); angiopathy (disturbance of vascular tone), trophic disorders (eating disorders of skin) for varicose varicose veins of the legs (venous changes, characterized by an uneven increase in their lumen with the formation of a diverticulum wall due to dysfunction of valvular), ulcers of different origin, bedsores (necrosis of tissue caused by prolonged pressure on them by lying down), burn prevention and treatment of radiation injuries .
Damage to the cornea (the clear covering the eye) and sclera (opacity of the eye): the burn of the cornea (acids, alkalis, lime), corneal ulcers of different origin, keratitis (inflammation of the cornea), including post-transplant (transplant), corneal abrasions of the cornea in patients contact lenses; prevention of defeats in the selection of contact lenses in patients with degenerative processes in the cornea (for use eye gel), as well as to accelerate the healing of venous ulcers (slow-healing skin defects), bedsores (necrosis of tissue caused by prolonged pressure on them by lying ), burns, radiation skin lesions, etc.
How to use:
Dose and route of administration depend on the type and severity of disease. The drug was appointed interior, parenterally (bypassing the digestive tract) and topically.
Inside the dosage is 1-2 pills 3 times daily before meals. Dragees not chew, washed down with sips of water.
For intravenous or intraarterial administration, depending on the severity of the disease starting dose is 10-20 ml. Then designate 5 ml by slow intravenous or intramuscular injection, 1 time a day every day or several times a week. Intravenously injected 250 ml solution for infusion at a rate of 2-3 ml per minute, a once daily or several times a week. You can also use 10, 20 or 50 ml solution for injection, diluted in 200-300 ml of glucose or saline. Total per course of treatment - 10-20 injections. In the infusion solution is not recommended to add other drugs.
Parenteral actovegin should be undertaken with caution because of the possibility of an anaphylactic (allergic) reaction. Recommended test administration, and the need to provide facilities for emergency treatment. Intravenously can be administered not more than 5 ml as hypertonic solution has the properties (osmotic pressure of the solution is higher than the osmotic pressure of blood). With intravenous drug use is recommended to monitor the performance of water-electrolyte metabolism.
Local application. Gel is indicated for the purification and treatment of open wounds and ulcers. For burns and radiation injuries gel applied to the skin with a thin layer. In the treatment of ulcers of the gel applied to the skin over a thick layer and cover wrap with ointment actovegin to prevent sticking to the wound. Dressing changes produce a once a week, with much weeping sores - several times a day.
Cream is used to improve wound healing, and weeping wounds. Use after the formation of pressure ulcers and prevention of radiation injuries.
The ointment is applied with a thin layer on the skin. Apply for the long-term treatment of wounds and ulcers in order to accelerate their epitelizaiii (healing) after treatment with gel or cream. For the prevention of pressure sores ointment should be applied to relevant areas of the skin. For the prevention of radiation skin lesions ointment should be applied after exposure or in the intervals between sessions.
Eye gel. In the affected eye directly from the tube squeezed a drop of gel. Apply 2-3 times a day. After opening the eye gel can be used not more than 4 weeks.
Side effects:
Allergic reactions: hives, feeling a rush of blood, sweating, increased body temperature. Itching, burning in the application of a gel, ointment or cream, the application of eye gel, lacrimation, scleral injection (redness of the sclera).
Contraindications:
Hypersensitivity to the drug. With care the drug during pregnancy. During the period of breast-feeding use actovegin undesirable.
Product:
Dragees forte in a package of 100 pieces. Solution for injection ampoules PA2, 5 and 10 ml (1 ml - 40 mg). Solution for infusion 10% and 20% with saline in vials of 250 ml. 20% gel in tubes of 1920 5% cream in tubes of 1920 5% Ointment in tubes of 1920 Eye Gel 20% in tubes of 5 g.
Storage Conditions:
In a dry place at temperatures no higher than 8 * C.
Ingredients:
Freed from the protein (deproteinized) extract (gemoderivat) from calf blood. Contains in 1 ml of 40 mg of dry matter.
