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  • Teturam tablets 150mg #50


    Manufacturer: Russia
    Product Code: 324
    Availability: On Recertification
    $10.40
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    Teturam (Disulfiram) is used to treat chronic alcoholism. It causes unpleasant effects when even small amounts of alcohol are consumed. 

    50 tablets 150mg

    Pharmacological action:
    Is taken orally for the treatment of chronic alcoholism in those cases when it is not possible to obtain a therapeutic effect other treatments (psychotherapy, vitamin therapy, receiving apomorphine, etc.).
    Effect of the drug based on its ability to specifically affect the exchange of alcohol in the body. Alcohol is subjected to oxidative transformations, passing through a phase of acetaldehyde and acetic acid. With the participation of atsetaldegidroksidazy acetaldehyde usually rapidly oxidized.
    Teturam blocking enzymatic biotransformation alcohol increases after the intake of alcohol in the blood concentration of acetaldehyde. According to current data is converted in the body teturam in N, N-diethyldithiocarbamic acid (DEDKK) and other metabolites, blocking metal ions and sulfhydryl groups of enzymes involved in the removal of alcohol. Accumulation after alcohol intake under the influence teturama acetaldehyde leads to severe for the patient changes in the body (the so-called effect of precipitates a): redness, heat sensation in the face and upper body, chest tightness, shortness of breath, buzzing in the ears, palpitations, fear, sometimes chills and others. significantly lowers blood pressure.

    Indications for use:
    Assigning alcohol on the background of teturama, produce negative conditioned reflex to the taste and smell of alcohol and long-term treatment achieve a partial or complete intolerance to alcohol.
    Teturama application may be accompanied by severe side effects, so people resort to it as one of the last resort.
    Before treatment the patient is subjected Teturamom careful medical examination. In the absence of contraindications to the patient explain the meaning of therapy and warn about the dangers of alcohol intake during the treatment period.

    How to use:
    Teturamom treatment is carried out under medical supervision. Dose picked individually. Optimal dose (0.25-0.5 g / day.) As a rule, well tolerated and does not give complications even after prolonged use. Doses teturama below 0.15 g / day. rapidly cleared from the body and do not cause the desired effect - sensibalizatsii (hypersensitivity) to alcohol.
    Teturamom treatment is usually carried out as follows. First teturam-alcohol test carried out after 7-10 days of starting treatment. After a morning reception 0.5-0.75 g teturama patient takes 20-30 ml of alcohol, usually 40% of vodka. Repeated tests carried out under stationary conditions in 1-2 days, out - after 3-5 days. With a weak dose response increase the alcoholic beverage at the next sample to 10-20 ml. The maximum dose of 100-120 ml of vodka. Teturam-alcohol reactions can be mild, moderate and severe. In severe reactions lasting 1-1.5 hours (severe headache with a feeling of fullness and pulsation, sharp shortness of breath, a significant decrease in blood pressure, blackout, psychomotor agitation / increased motor and speech activity / seizures) administered intravenously 15-20 ml 1% aqueous solution of methylene blue under the skin -kordiamin, camphor, intramuscularly - tsititon or lobeline, ephedrine, strychnine; produce oxygen inhalation. Glucose solution was administered intravenously with ascorbic acid. When the pain in the heart appoint validol Corvalol and, if necessary, nitroglycerin. Low blood pressure when administered metazon or ephedrine. In the case of sudden cardiac oppression injected 0.25-0.5 ml of a 0.05% solution strofantina in 20 ml of isotonic sodium chloride solution or 5% glucose solution. In convulsions - intramuscularly 10 ml of 25% magnesium sulfate solution. In severe nausea and vomiting injected 10 ml of a 10% solution of calcium chloride or gluconate give 0.015 g inwardly belladonna extract, subcutaneously administered 0.5 ml of a 0.1% solution of atropine. In case of convulsive reactions administered as an enema chloral hydrate (15-20 mL of 6% aqueous starch solution) or tranquilizers (sedative drugs); psychomotor agitation when administered intramuscularly 1-2 ml of 2.5% solution of chlorpromazine. The patient must be in a horizontal position.

    Side effects:
    When treating Teturamom particularly prolonged, can cause various disorders of the cardiovascular system, peripheral and central nervous system, the gastrointestinal tract and liver. Allergic reactions (itching, rash), and exacerbation of past diseases (gastritis / inflammation of the stomach / gastric ulcer and duodenal ulcer, gastric ulcer and duodenal ulcers, thrombophlebitis / inflammation of the walls of veins and their occlusion / etc.).
    In some cases, chronic administration of teturama may experience acute psychosis resembling acute alcoholic paranoid (conditions characterized by delusions of persecution, anxiety, fear, motor excitation), acute alcoholic gallyutsionoz (delirium, vision, acquiring the nature of reality) or delirium tremens (delirium). A transition hallucinatory paranoid syndrome, paranoid - in schizophrenia and so on. D.

    Contraindications:
    Relative contraindications are the residual effects of organic brain damage, age over 60 years, endarteritis (inflammation of the lining of the vessel), gastric ulcer and duodenal ulcer in acute, traumatic disease, residual effects after infection in the brain and stroke, previously transferred teturamovye psychosis.
    Absolute contraindications to the use of teturama are endocrine disorders (hyperthyroidism / thyroid disease / diabetes), pronounced cardio (excessive growth of connective tissue in the heart muscle), atherosclerosis of cerebral vessels, pre- and postinfarction state aneurysm (widening and / or bulging ) of the aorta, coronary insufficiency (mismatch of blood flow in heart arteries of the heart needs oxygen), hypertension II and IIIstady (persistent elevation of blood pressure), severe vascular disease of the brain, heart and vascular diseases in the stage of decompensation (at insufficiency), pulmonary tuberculosis with hemoptysis, fresh tuberculous infiltration (tissue regions of high density in the focus of tuberculous inflammation), bronchial asthma, severe emphysema (lung disease associated with an increased content of the air), a bleeding stomach ulcer, liver disease and kidney disease blood-forming organs, mental illness and infectious diseases of the brain, epilepsy and epileptiform syndromes, polyneuritis (inflammation of multiple peripheral nerves), neuritis (inflammation) of the auditory and optic nerve, glaucoma (increased intraocular pressure), malignancy, pregnancy, idiosyncrasy (hereditary hypersensitivity) to teturamu.

    Product:
    Tablets of 0.15 and 0.25 g, respectively, in units of 50 or 30 pieces.

    Storage conditions:
    List B. In dry, dark place.

    synonyms:
    Antabuse, Disulfiram, Abstinil, Alkofobin, Antetan, Antetil, anticol, Aversan, Kontrapot, Krotenal, Dizetil, Espen, Ekzorran, Nokzal, Refuzal, Stoptil, Tetradin.
     

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