Mode of action:
Has analgesic, anti-inflammatory and mild analgesic effect due to inhibition of the biosynthesis of prostaglandins by inhibiting the enzyme cyclooxygenase.
Pharmacokinetics
After ingestion is rapidly absorbed from the gastrointestinal tract. Maximum plasma concentration is determined after 1-2 h after administration, in the synovial fluid - 3 hours after admission. Metabolized in the liver. The half-life of about 2 hours excreted by the kidneys in unchanged form and as conjugates.
Used in cases:
• rheumatoid arthritis;
• osteoarthritis;
• ankylosing spondylitis;
• gout;
• neuralgia;
• myalgia;
• bursitis;
• sciatica;
• traumatic inflammation of soft tissue and musculoskeletal system;
• adnexitis (as part of combination therapy);
• proctitis (as part of combination therapy);
• diseases of upper respiratory tract (as part of combination therapy);
• headache (as an adjuvant);
• toothache (as an adjuvant).
How to use:
In rheumatoid arthritis appoint 800 mg 3 times / day.
In osteoarthritis, and ankylosing spondylitis Ibuprofen is used by 400-600 mg 3-4 times / day.
In juvenile rheumatoid arthritis, the drug is used at a dose of 30-40 mg / kg body weight / day.
For soft tissue injuries, sprains drug is prescribed 600 mg 2-3 times / day.
The pain syndrome of moderate-intensity drug administered 400 mg 3 times / day. The maximum daily dose of 2.4 g
Side effects:
Probably: nausea, anorexia, flatulence, constipation, heartburn, diarrhea, dizziness, headache, agitation, insomnia, allergic reactions such as skin rash, blurred vision. Cases of occurrence of erosive and ulcerative lesions of the gastrointestinal tract.
Rare: bleeding from the gastrointestinal tract, aseptic meningitis, bronchospasm.
Contraindications:
• erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
• "aspirin triad";
• violations of blood;
• ulcerative colitis;
• disease of the optic nerve;
• pronounced renal dysfunction and / or liver disease;
• Children under 6 years of age;
• hypersensitivity to the drug.
Pregnancy:
During pregnancy, the drug should be used only when prescribed by a physician.
Interactions with other drugs:
When concomitant administration of Ibuprofen may cause a decrease diuretic effect of furosemide.
In a joint application increases the effects of Ibuprofen difenina, coumarin anticoagulants, oral hypoglycemic agents.
Overdose:
With an overdose of ibuprofen are possible symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headaches, tinnitus, metabolic acidosis, coma, acute renal failure, hypotension, bradycardia, tachycardia, atrial fibrillation, and respiratory arrest.
Treatment: gastric lavage (only for the first hour after ingestion), activated charcoal (to reduce absorption), alkaline water, forced diuresis and symptomatic therapy (correction of acid-base balance, blood pressure, gastrointestinal bleeding).
Product:
100 coated tablets of 200 mg.
Storage:
Store in a dry, dark place.
Synonyms:
Advil, Apo-Ibuprofen, Barthel dragz ibuprofen Bonifen, Bren, Brufen, Buran, long, Ibupron, Ibuprofen, Ibuprofen Lannaher, Nycomed Ibuprofen, Ibuprofen-Teva, Ibusan, Ipren, Markofen, MIG 200, Motrin, Nurofen, profiles, Reumafen
Ingredients:
1 tablet contains 200 mg of ibuprofen.
In addition:
With care prescribe the drug to patients with impaired liver, kidney, cardiovascular system, with the guidance of a history of peptic ulcer and / or duodenal ulcer, bleeding from the gastrointestinal tract. Compared to other NSAID ibuprofen has the smallest ulcerogenic action on gastrointestinal mucosa.
With long-term use of the drug is necessary to monitor liver function and kidney picture of peripheral blood.
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