Gynoflor vaginal tablets #12

Gynoflor pharmachologic effect:
Lactobacillus acidophilus, are part of the drug Gynoflor are non-pathogenic bacteria, forming a healthy vaginal flora. They perform a protective function in the vagina by creating an acidic pH of the internal environment, which is unfavorable for the development and reproduction of pathogenic microorganisms. Lactobacillus acidophilus possess the ability to ferment vaginal epithelial glycogen to lactic acid. As a result, the pH in the vagina is supported by 4 - 4.5, which is not only unfavorable for the pathogen, but is optimum for the life of Lactobacillus acidophilus. Bacteria belonging to the drug during the life also produce bacteriocins and hydrogen peroxide, which have a bactericidal effect against pathogenic organisms.

Estriol - synthesized compound by the action similar to endogenous human hormones that are produced by the ovaries. No effect on the endometrium, acts only on the mucosal epithelium of the vagina. It stimulates the reproduction and growth of epithelial cells of the vaginal mucosa, significantly improving the condition of the vaginal epithelium. The resulting mature vaginal epithelium is not only a natural barrier to infection, but also contains glycogen, necessary for normal functioning of Lactobacillus acidophilus.
The drug is due to vaginal insertion of exogenous estriol and Lactobacillus acidophilus leads to normalization of the vaginal microflora, reduces the risk of local infections, improves the condition of the mucosa.
Part of the preparation Gynoflor lactose as Lactobacillus acidophilus fermented to lactic acid.

The drug acts locally and has no systemic effects. The release of the active ingredients of the drug takes place gradually, with the disintegration of the tablet. The action begins a few hours after injection.
Estriol intravaginal application when absorbed into the bloodstream, reaching a maximum concentration in plasma 3 hours after administration. Estriol Not accumulates in the body. It does not affect the production of endogenous estrogen hormones, as endogenous analog of estriol is the final step in the metabolism of estrogen hormones. Excreted in the urine within 8 hours.

Indications:

• Restoring vaginal flora after antibiotic therapy, topical or systemic antimicrobial or chemotherapeutic agents.
• During menopause in violation of the state of the vaginal epithelium, atrophic vaginitis.
• During menopause and menopause as a concomitant drug for hormone replacement therapy.
• Vaginal discharge of unknown origin.
• Candidiasis of mild to moderate severity, does not require specific treatment with antifungal agents. Prevention of relapse of candidiasis.
• Vaginitis, not complicated by infectious diseases.

Gynoflor mode of application:
The tablets are introduced into the vagina, pre-moistened with water. It is recommended to start therapy within a few days after the menstrual period, in order not to interrupt the course of treatment. Tablets are injected deep into the vagina at night before bedtime.
For infections, vaginal secretions, after antibiotic treatment to restore the microflora vaginal appoint 1-2 tablets a day. The course of treatment 6-12 days.
In atrophic vaginitis and vaginal secretions in menopausal and post-menopausal therapeutic dose - 1 tablet 1 time per day. The course of treatment 6-12 days after the course continue to support the introduction of a dose of 1 tablet 1-2 times a week.

If necessary, after 1-2 weeks, you can hold a second course of treatment, but this is usually not required, as the exogenous Lactobacillus acidophilus is well acclimatized and maintain a sufficient population to maintain normal vaginal microflora composition.
At the time of treatment is recommended to abstain from sex or use a barrier method of contraception.

Gynoflor side effects:
The drug is generally well tolerated, however, in some cases, possibly a burning sensation and discomfort after the injection. There are also allergic reactions such as redness and swelling of the vaginal mucosa and the external genitalia. There may be itching after treatment. These side effects usually disappear 2-3 days of use and do not require discontinuation of therapy.
In case of accidental ingestion by mouth should not expect negative consequences.

Gynoflor contraindications:

• Individual hypersensitivity to the drug.
• Age before puberty.
• Vaginal bleeding of unknown etiology.
• Estrogen-dependent cancer, particularly breast cancer, uterus or vagina, including the anamnesis.
• Endometriosis Endometriosis or suspected.

Gynoflor during pregnancy:
The drug can be used during pregnancy and lactation. The components of the drug did not have embryotoxic, teratogenic and mutagenic effects on the fetus. However, caution should be prescribed the drug in the first trimester of pregnancy.

Interaction with other drugs:
The bacteria contained in the preparation Gynoflor sensitive to many antimicrobial local and systemic effects, so during antibiotic therapy simultaneously using Gynoflor reduce its effectiveness.

Overdose:
Currently no reported cases of overdose have been reported.

Product:
Vaginal tablets of 50mg, 6 pills in a blister, 2 blisters in carton.

Gynoflor storage conditions:
The drug should be stored in a dry dark place at a temperature of 2 degrees C to 8 degrees Celsius. Short (up to 2 weeks) Gynoflor storage at a temperature of 15 degrees Celsius to +25 degrees Celsius does not reduce its effectiveness.
Shelf life - 3 years.

Gynoflor synonyms:

• Vagilak

Composition:
1 vaginal tablet formulation Gynoflor includes:

• Lyophilizate Lactobacillus acidophilus - 50mg (which is not less than 100 million viable bacteria Lactobacillus acidophilus);
• Estriol - 0,03mg.
• Excipients including lactose.

Pharmacological group:
Antimicrobial and antiparasitic drugs
Complex antimicrobials

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