Afobazol 10 mg (60 tablets)
Used to treat: anxiety accompanied by feelings of anxiety, fear, irritability, emotional lability, anxiety, arousal, generalized anxiety disorder, neurasthenia, adjustment disorders, somatic diseases and conditions (asthma, irritable bowel syndrome, systemic lupus erythematosus, ischemic heart disease, hypertension, arrhythmia, cardiopsychoneurosis , premenstrual syndrome, menopausal syndrome, alcohol withdrawal syndrome), skin, cancer and other diseases; dissomniya associated with feelings of anxiety, to suppress the effects of withdrawal in smoking cessation.
Mode of action:
The active ingredient of the drug - selective anxiolytic, not related to the class of benzodiazepine receptor agonists. Prevents the development of membrane changes in the receptors sensitive to gamma-aminobutyric acid. The action is not accompanied by gipnosedativny effects. It has no muscle relaxant properties, negative effect on memory and concentration. Even with a long reception Afobazol not develop drug dependence, there is no withdrawal. By stabilizing the membrane GABA receptors has a dual effect on the human body, at the same time providing an anxiolytic (antianxiety) and light stimulating effect. Reducing psychological distress caused by anxiety states (concerns foreboding, fear, irritability) and the effects of emotional stress (fearfulness, tearfulness, anxiety, inability to relax, irrational fear, insomnia) lead to the improvement of the general condition of the body, including the improvement of the physical condition.
State of psychological well-being leads to improvement in a variety of physical, cognitive and autonomic disorders. Including eliminates muscle, sensory, cardiovascular, respiratory, gastro-intestinal symptoms of somatic disorders. Reduces the frequency of occurrence of autonomic disorders, including dry mouth, sweating, and dizziness. The drug increases the ability to concentrate, improves memory. Improvement is seen at 5-7 days of treatment. The maximum effect is achieved by 4 weeks of treatment and persist after discontinuation an average of 1-2 weeks, depending on the characteristics of each individual patient metabolism. Better use of the drug in the treatment of patients with predominantly asthenic personality traits. Such people are usually characterized by mistrust, insecurity, increased vulnerability and emotional lability. The drug is well absorbed from the gastrointestinal tract has a high degree of plasma protein binding and high affinity to the body cells. The drug belongs to a category of drugs that are rapidly cleared from the body, thus reducing the risk of overdose Afobazol. The half-life of 0.82 hours.
Indications for use:
It is used in adults with anxiety: generalized anxiety disorder, neurasthenia, adjustment disorder.
With somatic diseases: asthma, irritable bowel syndrome, systemic lupus erythematosus, hypertension, coronary heart disease, arrhythmias.
If there are indications for dermatological and oncological diseases.
In the treatment of sleep disorders, neuro dystonia, premenstrual syndrome.
For the treatment of alcohol withdrawal syndrome, and ease withdrawal symptoms during smoking cessation.
How to use:
Inside, the preferred reception after the meal. The dose is adjusted individually. The initial single dose 10mg daily - 30 mg. If necessary, the dose was increased to 60mg per day. The course of treatment is 2-4 weeks, if indicated by the attending physician may prolong the course of up to 3 months or reappointed after a certain period of time.
Side effects:
May develop allergic reactions, nausea, vomiting, diarrhea.
Contraindications:
Children up to age 18;
During pregnancy and lactation;
Hypersensitivity of the components of the drug;
Lactose intolerance (hypolactasia).
Pregnancy:
Use of the drug is contraindicated in pregnancy. The drug is excreted in breast milk, so with a drug to raise the issue of termination of breastfeeding.
Interactions with other drugs:
Mutual potentiation observed while taking the drug Afobazol and diazepam. Enhances the anticonvulsant effect of carbamazepine. No effect on the narcotic effect of ethanol and the hypnotic effect of thiopental.
Overdose:
If a large overdose may be a manifestation of sedation, as well as increased sleepiness without evidence of muscle relaxation. No specific antidote. As an emergency room not use caffeine sodium benzoate 20% solution in ampoules of 1.0 ml 2-3 times a day subcutaneously.
Product:
Tablets 10 tablets in blister of 3, 5 or 10-outline packages in a cardboard box;
Tablets of 25 tablets in blister of 2 or 4-outline packages in a cardboard box;
30, 50 or 100 tablets polymer jar with lid.
Storage:
In the dark and dry place at a temperature no higher than 25 degrees Celsius.
Shelf life - 2 years.
Ingredients:
1 tablet contains:
Afobazol (based on the dry matter) - 5 or 10 mg;
Additional ingredients: potato starch, microcrystalline cellulose, milk sugar (lactose), povidone, magnesium stearate.
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